Eribulin

Eribulin

White to off-white crystalline powder

Purity ≥ 98.0% (HPLC basis)

Eribulin is a non-taxane microtubule dynamics inhibitor used in oncology for the treatment of advanced solid tumors. It exerts its antitumor effect by binding to the growing ends of microtubules, causing irreversible mitotic arrest and apoptosis. In addition, it suppresses epithelial-to-mesenchymal transition (EMT), reduces tumor cell motility and invasiveness, and remodels tumor vasculature.

Metastatic Breast Cancer (MBC):
Eribulin is approved for the treatment of locally advanced or metastatic breast cancer in patients who have received at least two prior chemotherapeutic regimens, including an anthracycline and a taxane.
Clinical benefits include:
Significant improvement in overall survival (OS) compared to physician's choice chemotherapy.
Demonstrated efficacy in triple-negative breast cancer (TNBC), a subtype associated with poor prognosis and limited treatment options.
Shown to reverse EMT, leading to increased tumor sensitivity to chemotherapy.
Reduces tumor invasion and migration, thereby limiting metastatic spread.

Unresectable or Metastatic Liposarcoma:
Eribulin is also indicated for the treatment of advanced liposarcoma, particularly after failure of prior anthracycline-based chemotherapy.
Key clinical features:
The only single agent shown to prolong overall survival in liposarcoma in a Phase III trial.
Effective in dedifferentiated, pleomorphic, and myxoid/round cell subtypes.
Offers treatment benefit even in highly refractory tumors and patients with poor performance status.
Slows tumor progression and improves quality of life in soft tissue sarcoma patients.

Investigational and Off-Label Uses:
Eribulin is under investigation in:
Non-small cell lung cancer (NSCLC)
Platinum-resistant ovarian cancer
Soft tissue sarcomas other than liposarcoma
Endometrial and gastrointestinal cancers
Combination therapies with immune checkpoint inhibitors and antiangiogenic agents

Conforms to USP and EP.

Store at 2°C to 8°C, protected from light and moisture.
Keep in a tightly sealed container in a dry place.
Stable for transport under ambient conditions for a limited period.

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