Retatrutide

Retatrutide

White to off-white amorphous or crystalline powder

Purity ≥ 98.0% (HPLC basis)

Retatrutide is an investigational multi-receptor peptide agonist with activity at GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. It is being developed as a next-generation therapy for type 2 diabetes, obesity, and metabolic syndrome, with the potential for broader therapeutic impact.

Type 2 Diabetes Mellitus (T2DM):
Retatrutide improves glycemic control through a triple mechanism:
Stimulates insulin secretion in a glucose-dependent manner
Reduces glucagon secretion to suppress hepatic glucose output
Enhances insulin sensitivity and β-cell function
In clinical trials, Retatrutide has shown greater reductions in HbA1c compared to current incretin-based therapies, including GLP-1 and dual agonists like tirzepatide.

Obesity and Weight Management:
Retatrutide is one of the most promising anti-obesity drug candidates, with weight loss effects exceeding 24% of baseline body weight in some clinical studies. It:
Reduces appetite and caloric intake via central satiety mechanisms
Increases energy expenditure through glucagon receptor activity
Promotes lipolysis and fat oxidation
Improves metabolic parameters including blood lipids, blood pressure, and waist circumference

Non-Alcoholic Steatohepatitis (NASH):
Ongoing clinical development includes evaluation for NASH and NAFLD, due to Retatrutide's ability to:
Reduce hepatic fat accumulation
Improve liver enzymes and inflammatory markers
Potentially reverse fibrosis in early stages

Cardiometabolic Syndrome and Related Disorders:
Because of its broad metabolic effects, Retatrutide is also a candidate for:
Atherosclerotic cardiovascular disease risk reduction
Polycystic ovary syndrome (PCOS)
Prediabetes and insulin resistance syndromes
Sleep apnea and dyslipidemia
Its multi-receptor activity is uniquely positioned to address the interconnected pathology of obesity, insulin resistance, and cardiovascular disease.

Conforms to USP and EP.

Store at -20°C, protected from light and moisture, in a tightly sealed container.
Avoid repeated freeze-thaw cycles.
Recommended to store under nitrogen or inert gas for long-term stability.

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