Product Name
Methyldopa
CAS Number
555-30-6
Molecular Formula
C10H13NO4
Appearance
White or off-white crystalline powder
Description
Methyldopa is a centrally acting antihypertensive drug that lowers blood pressure by reducing sympathetic nerve activity. As an α2-adrenergic agonist, it decreases vascular resistance and cardiac output, making it effective for long-term hypertension management. Due to its well-established safety profile, it is particularly recommended for treating hypertension during pregnancy. It is widely used in clinical settings for managing chronic hypertension and preventing cardiovascular complications associated with high blood pressure.
Uses
Treatment of Hypertension
Used for managing mild to moderate hypertension in adults.
Reduces blood pressure by decreasing peripheral vascular resistance while maintaining cardiac output and renal blood flow.
Effective as a monotherapy or in combination with other antihypertensive agents.
01
Preferred Antihypertensive in Pregnancy
One of the safest drugs for managing hypertension in pregnant women, particularly in cases of gestational hypertension and preeclampsia.
Does not significantly affect uteroplacental blood flow, ensuring fetal safety.
02
Long-Term Blood Pressure Control
Often used for chronic hypertension management, especially when β-blockers or diuretics are not suitable.
Helps prevent complications related to uncontrolled hypertension, such as stroke and heart failure.
03
Mechanism of Action
Methyldopa is metabolized into α-methyl norepinephrine, which stimulates central α2-adrenergic receptors.
This leads to reduced sympathetic nerve activity, vasodilation, and decreased blood pressure.
04
Additional Effects
Can lower plasma renin activity, further contributing to blood pressure reduction.
Has mild sedative properties, which may benefit patients with stress-induced hypertension.
05
Quality Standards
- Standards: Conforms to USP and EP
- Purity: ≥ 98%
- Identification: Meets USP/BP/EP standards
- Heavy Metals: Lead ≤ 10 ppm, Arsenic ≤ 3 ppm, Cadmium ≤ 1 ppm
- Loss on Drying: ≤ 1.0%
- Microbial Limits: Total Plate Count ≤ 1000 cfu/g, E. coli Negative, Salmonella Negative
Storage Conditions
- Store in a cool, dry place, away from light and moisture.
- Keep in a tightly sealed container to prevent degradation.
- Recommended storage temperature: 15-25°C.
- Protect from excessive heat, humidity, and oxidation.
References：
https://en.wikipedia.org/wiki/Methyldopa
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