Product Name
Carbidopa
CAS Number
388-61-1
Molecular Formula
C10H14N2O4
Appearance
White to off-white crystalline powder
Description
Carbidopa is a medication used primarily in the treatment of Parkinson's disease in combination with levodopa. It works by inhibiting the enzyme aromatic L-amino acid decarboxylase (AAAD), which prevents the premature conversion of levodopa to dopamine outside the brain. This allows more levodopa to reach the brain, where it can be converted into dopamine to help control symptoms of Parkinson's disease, such as tremors, stiffness, and bradykinesia.
Uses
Parkinson's Disease Treatment
Levodopa Combination Therapy: Carbidopa is most commonly used in combination with levodopa to treat Parkinson's disease. It helps reduce the side effects of levodopa, such as nausea and vomiting, by inhibiting the premature conversion of levodopa into dopamine outside the brain. This ensures that more levodopa reaches the brain for optimal therapeutic effects.
Symptom Control: When used together, carbidopa and levodopa help control motor symptoms of Parkinson's disease, such as tremors, rigidity, and slow movements. It improves quality of life and motor function for patients.
Dopaminergic Effects Enhancement
Carbidopa enhances the efficacy of levodopa therapy by allowing higher doses of levodopa to be administered, leading to better control over Parkinson's symptoms. It prevents the peripheral side effects of levodopa, making it a more tolerable treatment option.
Treatment of Other Dopaminergic Disorders (Off-Label Use)
In some cases, carbidopa is used off-label to treat other conditions that involve dopaminergic deficits, although its primary use is for Parkinson's disease.
Quality Standards
- Standards: Conforms to USP and EP
- Purity: ≥ 98%
- Identification: Meets USP/BP/EP standards
- Heavy Metals: Lead ≤ 10 ppm, Arsenic ≤ 3 ppm, Cadmium ≤ 1 ppm
- Loss on Drying: ≤ 1.0%
- Microbial Limits: Total Plate Count ≤ 1000 cfu/g, E. coli Negative, Salmonella Negative
Storage Conditions
- Store in a cool, dry place, away from direct sunlight and moisture.
- Keep in a tightly sealed container to prevent degradation.
- Recommended storage temperature: 15-25°C.
- Protect from excessive heat and humidity to maintain stability.
https://en.wikipedia.org/wiki/Carbidopa
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