Product Name
Cefuroxime Axetil
CAS Number
56456-04-1
Molecular Formula
C20H22N6O5S
Appearance
White to off-white crystalline powder
Description
Cefuroxime axetil is an oral prodrug of cefuroxime, a second-generation cephalosporin antibiotic. It is used to treat a wide variety of bacterial infections by inhibiting bacterial cell wall synthesis. Cefuroxime axetil is more stable in the gastrointestinal tract compared to cefuroxime, making it suitable for oral administration.
Uses
Respiratory Tract Infections
Community-Acquired Pneumonia (CAP): Cefuroxime axetil is effective in treating bacterial pneumonia caused by organisms such as Streptococcus pneumoniae and Haemophilus influenzae.
Acute Otitis Media: Used to treat middle ear infections, commonly caused by Streptococcus pneumoniae and Moraxella catarrhalis.
Chronic Sinusitis: Effective in treating bacterial sinus infections, including those resistant to other antibiotics.
Urinary Tract Infections (UTIs)
Used for uncomplicated and complicated UTIs, including cystitis and pyelonephritis, caused by bacteria like Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
Skin and Soft Tissue Infections
Treats conditions such as cellulitis, impetigo, and abscesses, often caused by Staphylococcus aureus and Streptococcus pyogenes.
Also used in treating infections from surgical wounds.
Gastrointestinal Infections
Effective against infections like Salmonella and Shigella caused by gram-negative bacteria.
Used in cases of diverticulitis and other intra-abdominal infections.
Surgical Prophylaxis
Prevents infections following certain types of surgery, especially abdominal or gynecological procedures, due to its effectiveness against common skin flora and gastrointestinal pathogens.
Lyme Disease
Cefuroxime axetil is also used in the treatment of early stages of Lyme disease caused by Borrelia burgdorferi.
Quality Standards
- Standards: Conforms to USP and EP
- Purity: ≥ 98%
- Heavy Metals: Lead ≤ 10 ppm, Arsenic ≤ 3 ppm, Cadmium ≤ 1 ppm
- Microbial Limits: Total Plate Count ≤ 1000 cfu/g, E. coli Negative, Salmonella Negative
- Solubility: Soluble in water (after hydrolysis to cefuroxime), slightly soluble in ethanol.
Storage Conditions
- Store in a cool, dry place, away from direct sunlight and moisture.
- Keep the container tightly closed.
- Ideal storage temperature: 15-30°C.
- Protect from light and humidity to maintain stability.
References：
https://en.wikipedia.org/wiki/Cefuroxime_axetil
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