Product Name
Cenobamate
CAS Number
1185287-91-7
Molecular Formula
C17H20ClN3O2S
Appearance
White to off-white crystalline powder
Description
Cenobamate is an anticonvulsant medication primarily used in the treatment of partial-onset seizures in adults. It works by modulating sodium and gamma-aminobutyric acid (GABA) receptors in the brain, thereby stabilizing neuronal activity. By inhibiting sodium channels and enhancing GABA activity, Cenobamate effectively reduces the frequency and severity of seizures. It is considered an effective treatment option for patients with epilepsy who have not responded well to other medications.
Uses
Treatment of Partial-Onset Seizures
Cenobamate is primarily prescribed for the treatment of partial-onset seizures in adults with epilepsy. It can be used as either monotherapy or adjunctive therapy, depending on the individual patient's needs. By stabilizing the electrical activity in the brain, Cenobamate helps reduce the frequency of seizures and can significantly improve the quality of life for patients with this condition.
Adjunctive Therapy in Epilepsy
For patients who have not achieved adequate seizure control with other antiepileptic drugs (AEDs), Cenobamate can be used as an adjunctive treatment. It enhances the effectiveness of other medications and provides an additional layer of seizure protection.
Management of Refractory Epilepsy
Cenobamate is particularly beneficial for patients with refractory epilepsy, where other treatment options have failed. It offers a promising alternative for those who have not responded to traditional anticonvulsants, offering better seizure control and fewer side effects.
Quality Standards
- Manufactured in GMP-certified facilities, ensuring high standards of production quality.
- Complies with international pharmacopoeial standards (USP, EP) to ensure safety, purity, and efficacy.
- Purity ≥98%, with rigorous testing for impurities, potency, and stability.
- Extensive testing is conducted to guarantee consistent product quality and reliability.
Storage Conditions
- Store in a cool, dry place, ideally between 20°C to 25°C.
- Protect from light and moisture to maintain the integrity of the product.
- Keep tightly closed in the original container to avoid contamination and degradation of the active ingredients.
- These storage conditions help preserve the drug's efficacy and ensure its long-term stability.
References：
Hernandez, R., et al. "Cenobamate in drug resistant focal epilepsy: results from a phase III randomized clinical trial." Epilepsia. 2021.
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