Product Name
Polyvinylpyrrolidone (PVP)
CAS Number
9003-39-8
Molecular Formula
(C6H9NO)n
Appearance
White to off-white, fine, crystalline powder or a white to yellowish powder in its non-crystalline form. It is soluble in water and polar solvents.
Description
Polyvinylpyrrolidone (PVP) is a water-soluble polymer made by polymerizing N-vinylpyrrolidone (NVP). It is a hygroscopic material that is available in several molecular weight grades. The polymer has a wide range of uses in pharmaceutical, cosmetic, food, and industrial applications. Due to its excellent solubility in water and many organic solvents, it has versatile functionalities including thickening, stabilizing, dispersing, and film-forming properties. PVP is biocompatible and non-toxic, making it an ideal ingredient for use in medical and pharmaceutical formulations.
Uses
Binder and Disintegrant in Tablets
PVP is used as a binder in tablet formulations, helping to hold the active ingredients together. It also functions as a disintegrant, promoting the breakdown of tablets upon ingestion, which ensures the rapid release of the active pharmaceutical ingredients (APIs) into the digestive system.
01
Film-forming Agent
PVP is commonly used in film coatings for tablets and granules. It provides a smooth, stable coating that protects the active ingredients from moisture and light, while also allowing for controlled drug release. PVP is used to create both immediate and sustained-release dosage forms.
02
Suspending Agent in Liquids
Due to its excellent solubility and thickening properties, PVP is often used as a suspending agent in oral suspensions and injectables. It ensures that insoluble drug particles remain evenly dispersed, preventing settling and enhancing the homogeneity of the formulation.
03
Plasma Expanders in Intravenous Solutions
PVP is used as a plasma expander in intravenous solutions. It helps increase blood volume in emergency medical situations, such as shock or trauma, by expanding the plasma volume and maintaining blood pressure.
04
Wound Healing and Topical Applications
PVP has applications in topical formulations such as wound dressings and ointments. It provides a protective film that aids in the healing process while delivering active ingredients to the skin.
05
Quality Standards
- Standards: Conforms to USP and EP
- Purity (Dry Basis): ≥ 99%
- Viscosity (1% Aqueous Solution): Depending on the molecular weight, typically 2 – 30 cP
- pH (1% Aqueous Solution): 4.5 – 7.0
Storage Conditions
- Store in a cool, dry place, away from direct sunlight and moisture to avoid degradation or clumping of the powder.
- Keep the container tightly closed to prevent contamination and moisture absorption.
- Recommended storage temperature: 15°C - 25°C.
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