Product Name
PEARLITOL-ROQUETTE
CAS Number
69-65-8
Molecular Formula
C₆H₁₄O₆
Appearance
White crystalline powder or granules, odorless and mildly sweet taste.
Description
PEARLITOL-ROQUETTE is a sugar alcohol used primarily as an osmotic diuretic and a laxative. It also serves as a stabilizer in pharmaceutical formulations and is widely used in medical and food applications due to its low-calorie content and non-glycemic properties.
Uses
Medical Applications
Intracranial Pressure: Mannitol is commonly used in emergency medicine to reduce cerebral edema (swelling in the brain) and lower intracranial pressure (ICP), especially after head trauma or surgery.
Acute Glaucoma: It is also used to treat acute glaucoma by reducing intraocular pressure (IOP) in the eye, particularly during surgeries or emergency treatment.
Renal Protection: Mannitol can be used to prevent renal failure by promoting urine production in patients with kidney dysfunction or after certain surgeries.
Toxicity Treatment: Mannitol is used in certain poisoning cases, as it helps in the enhanced renal excretion of toxins, such as heavy metals or other drugs, thereby promoting their removal from the body.
Pharmaceutical Formulations
Stabilizer for Biologics: PEARLITOL-ROQUETTE is commonly used as a stabilizer in injectable biologic formulations, particularly for proteins, peptides, and vaccines. It helps maintain the structural integrity of these complex molecules during storage and transportation.
Injectable Solutions: It is frequently included in IV solutions, both for its diuretic effects and as an excipient in other drug formulations, ensuring stability and solubility of active ingredients.
Oral Medications: Used in oral formulations, especially for low-calorie medications or to enhance the palatability of certain liquid drugs, thanks to its sweet taste.
Food and Beverage Industry
Utilized as a low-calorie sweetener in sugar-free products, candies, and gums.
Industrial Applications
Applied in the production of cosmetics, and as a packing material in the pharmaceutical industry.
Quality Standards
- Standards: Conforms to USP and EP
- Purity: ≥ 98%
- Microbial Limits: Complies with standard microbial limits for pharmaceutical excipients.
Storage Conditions
- Store in a cool, dry place, away from direct sunlight.
- Keep in tightly closed containers to prevent moisture absorption.
- Recommended storage temperature: < 25°C.
https://www.ncbi.nlm.nih.gov/search/all/?term=PEARLITOL
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