Product Name
Amikacin
CAS Number
37517-28-5
Molecular Formula
C22H43N5O13
Appearance
White to off-white crystalline powder
Description
Amikacin is a potent aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is highly effective against a broad spectrum of Gram-negative bacteria, including multidrug-resistant strains, and is used for treating serious infections, particularly in hospitalized patients. Amikacin also demonstrates activity against some Gram-positive bacteria, making it an important option for severe and life-threatening infections.
Uses
Severe Infections
Gram-negative Infections: Used for infections caused by Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and other Gram-negative bacteria, including sepsis, pneumonia, and urinary tract infections.
Intra-abdominal Infections: Effective in treating peritonitis, diverticulitis, and other abdominal infections, often in combination with other antibiotics.
Respiratory Tract Infections
Used for treating hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) caused by multidrug-resistant pathogens.
Urinary Tract Infections (UTIs)
Effective against complicated and uncomplicated UTIs caused by resistant Gram-negative bacteria, especially E. coli and Klebsiella species.
Soft Tissue and Bone Infections
Treats severe skin and soft tissue infections, including those caused by Pseudomonas and Staphylococcus aureus.
Used in bone infections (osteomyelitis), particularly when resistant organisms are involved.
Tuberculosis (TB)
Amikacin is sometimes used as part of combination therapy for multidrug-resistant tuberculosis (MDR-TB) when first-line drugs are ineffective.
Neonatal Infections
Used in neonates for serious infections, including sepsis and pneumonia, due to its broad-spectrum activity against resistant pathogens.
Quality Standards
- Standards: Conforms to USP and EP
- Purity: ≥ 98%
- Heavy Metals: Lead ≤ 10 ppm, Arsenic ≤ 3 ppm, Cadmium ≤ 1 ppm
- Microbial Limits: Total Plate Count ≤ 1000 cfu/g, E. coli Negative, Salmonella Negative
- Solubility: Soluble in water, slightly soluble in ethanol.
Storage Conditions
- Store in a cool, dry place, away from direct sunlight.
- Keep the container tightly closed.
- Ideal storage temperature: 15-25°C.
- Protect from moisture and light to maintain stability.
References：
https://en.wikipedia.org/wiki/Amikacin
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