Retatrutide Intermediate

Retatrutide Intermediate

Fmoc- L- Lys [ C20- OtBu- Glu (OtBu) - AEEA]- OH CAS# : 2612237-97-3
Boc-Tyr (tBu)- Aib- Gln (Trt)- Gly- OH CAS#: 2612237-79-1

White to off-white powder or crystalline solid (depending on the specific intermediate)

Purity ≥ 95.0% ( HPLC basis)
Single Impurity ≤ 1.0%
Identity confirmed by Mass Spectrometry and NMR (where applicable)

This intermediate is not for direct therapeutic use but is a critical component in the synthesis of Retatrutide, a triple agonist peptide (GLP-1, GIP, and Glucagon receptors) under clinical development for multiple metabolic disorders.
Final API – Retatrutide – Target Indications:

Type 2 Diabetes Mellitus (T2DM):
By stimulating insulin release, inhibiting glucagon secretion, and improving peripheral insulin sensitivity, Retatrutide lowers HbA1c more effectively than single or dual incretin therapies.

Obesity and Weight Loss Therapy:
Retatrutide intermediates enable the construction of a peptide chain that delivers unprecedented clinical results in weight management. Clinical trials have shown:
Up to 24% body weight reduction
Improved BMI, waist circumference, lipid profiles
Reduced appetite, improved satiety, and increased thermogenesis

NASH and NAFLD:
Intermediate peptides used in Retatrutide synthesis are essential in delivering liver-targeted effects through the glucagon receptor. Retatrutide shows promise in:
Reducing hepatic steatosis
Lowering ALT/AST levels
Reversing early-stage fibrosis

Additional Potential Applications:
Due to its triple agonist nature, the finished peptide (assembled from intermediates) is under investigation for:
Cardiometabolic disease prevention
PCOS management
Weight-related hypertension and dyslipidemia
Improvement of insulin resistance syndromes
Cardiovascular risk reduction in obese or diabetic populations

Conforms to internal synthesis specifications equivalent to research- or GMP-grade intermediates for regulated peptide manufacturing.

Store at -20°C, protected from moisture and light.
Keep in sealed container under inert atmosphere (e.g., nitrogen or argon).
Avoid exposure to repeated freeze-thaw cycles.
Use within designated retest period to maintain optimal chemical and structural integrity.

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