6-APA

6-APA

Product Name: 6-Aminopenicillanic Acid (6-APA)
CAS Number: 71-53-2
Molecular Formula: C8H10N2O3S
Appearance: White to off-white crystalline powder
Send Inquiry

Product Name

 

6-Aminopenicillanic Acid (6-APA)

 

CAS Number

 

71-53-2

 

Molecular Formula

 

C8H10N2O3S

 

Appearance

 

White to off-white crystalline powder

 

Description

 

6-Aminopenicillanic Acid (6-APA) is a key intermediate in the production of penicillin derivatives. It is the core structure of the penicillin molecule and is essential for the synthesis of various semisynthetic antibiotics. 6-APA is produced by hydrolyzing penicillin G, and its derivatives are used to produce a wide range of penicillin-based antibiotics with improved pharmacological properties, including broader-spectrum activity and resistance to β-lactamases.

 

Uses

 

Synthesis of Semisynthetic Penicillins

6-APA is primarily used as a key starting material for the production of semisynthetic penicillins. These penicillins, such as amoxicillin, ampicillin, and piperacillin, offer broader antibacterial activity and are more effective in treating infections caused by both Gram-positive and Gram-negative bacteria.

01

Development of New Penicillin Derivatives

Pharmaceutical companies use 6-APA to create new penicillin derivatives tailored to combat emerging resistant bacterial strains or to treat more complex infections.

By altering the side chains attached to the 6-APA molecule, scientists can develop antibiotics with improved activity against specific bacterial pathogens.

02

Antibacterial Treatment

Penicillin derivatives derived from 6-APA, such as amoxicillin and ampicillin, are widely used to treat infections such as respiratory tract infections, urinary tract infections, skin infections, and gastrointestinal infections. These antibiotics are among the most prescribed and are commonly used in both oral and intravenous formulations.

03

Pharmaceutical Manufacturing

6-APA is crucial in the large-scale manufacturing of penicillin-based antibiotics. It is used by pharmaceutical manufacturers to produce antibiotics in various dosage forms, including tablets, capsules, suspensions, and injectables. These formulations are essential for the treatment of bacterial infections in a wide range of patients, from children to adults.

04

Research and Development in Antimicrobial Agents

6-APA is a fundamental compound in antibiotic research, facilitating the development of novel antimicrobial agents. It is used in research laboratories to create compounds that may be effective against resistant bacteria, contributing to the ongoing efforts to develop new treatments for bacterial infections.

05

 

Quality Standards

 

  • Standards: Conforms to USP and EP
  • Purity: ≥ 98%
  • Identification: Meets USP/BP/EP standards
  • Heavy Metals: Lead ≤ 10 ppm, Arsenic ≤ 3 ppm, Cadmium ≤ 1 ppm
  • Loss on Drying: ≤ 1.0%
  • Microbial Limits: Total Plate Count ≤ 1000 cfu/g, E. coli Negative, Salmonella Negative

 

Storage Conditions

 

  • Store in a cool, dry place, away from light and moisture.
  • Keep in a tightly sealed container to prevent degradation.
  • Recommended storage temperature: 15-25°C.
  • Protect from excessive heat, humidity, and oxidation.

 

https://www.ncbi.nlm.nih.gov/search/all/?term=6-Aminopenicillanic+Acid 

Hot Tags: 6-apa, China 6-apa manufacturers, suppliers, Cimetidine Tablets, Edaravone 251107 28 9, powder for injection, Citicoline Sodium Injection, Cefoperazone Sodium and Sulbactam Sodium for Injection, Acetylglutamide for Injection