What Are The Hazards Of Long-term Consumption Of Paliperidone

Long term consumption of Paliperidone may bring the following risks:
1. Risk of gastrointestinal injury: Long term use of Paliperidone may increase the burden on the gastrointestinal tract, leading to symptoms such as upper abdominal pain, nausea, belching, and possibly digestive disorders. In addition, there is also a possibility of gastrointestinal obstruction.
2. Risk of cardiovascular and cerebrovascular adverse events: Long term use of paliperidone may lead to palpitations, bradycardia, prolonged QT interval, orthostatic hypotension, and even prolonged ischemia of myocardial tissue, resulting in syncope. At the same time, it also increases the likelihood and risk of stroke.
3. Risk of allergic reactions: Some patients may experience allergic reactions after taking medication, such as skin rashes, itching, pain, etc. In severe cases, there may be redness, swelling, blistering, or peeling of the skin with or without fever, itching, rash, and even difficulty breathing, swallowing, or speaking, as well as swelling of the skin surface, tongue, and throat.
4. Risk of neurological damage: Paliperidone may increase the mortality rate of elderly dementia related psychiatric patients, increase the sensitivity of Parkinson's disease or Lewy body dementia patients, and may also lead to potential cognitive and motor dysfunction as well as late-onset motor impairment. For epilepsy patients, it may also trigger epileptic seizures.
5. Risk of hematological abnormalities: Paliperidone can affect metabolic or hemodynamic responses, leading to conditions such as leukopenia, neutropenia, granulocytopenia, and thrombotic thrombocytopenic purpura.
6. Other risks include hyperprolactinemia, difficulty swallowing, abnormal penile erection, disruption of thermoregulation, and metabolic changes. In addition, it may also increase the risk of suicide.
When using Paliperidone, it is necessary to strictly follow the doctor's advice and avoid choosing the medication or increasing the dosage on your own. If there are obvious discomfort symptoms, such as dizziness, nausea, fatigue, etc., the medication should be stopped immediately and the doctor should be informed to minimize the risks to the body caused by the medication.